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LexicMap: efficient sequence alignment against millions of prokaryotic genomes​
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  3. Notes
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  5. Motivation

Motivation

  1. BLASTN cannot scale to millions of bacterial genomes: it is slow and has high memory usage. For example, it requires >2000 GB to align a 2-kb gene sequence against all 2.34 million prokaryotic genomes in Genbank and RefSeq.

  2. Large-scale sequence searching tools only return which genomes a query matches (color), but they can’t return positional information.

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